Statistical theory of mixed-valence selectivity in biological ion channels

Gibby, William A. T. and Barabash, Miraslau L. and Guardiani, Carlo and Luchinsky, Dmitry G. and McClintock, Peter V. E. (2019) Statistical theory of mixed-valence selectivity in biological ion channels. In: 25th International Conference on Noise and Fluctuations, 2019-06-18 - 2019-06-21, EPFL.

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Abstract

In this article we apply our multi-component statistical and linear response theory to the process of mixed-valence ionic transport in a biological sodium ion channel. We analyse the free energy spectra, and statistical fluctuations (which are proportional to the conductivity) to investigate conditions and optimal parameters required for selectivity.