Skwarczynska, Agata L. and Binias, Dorota and Maniukiewicz, Waldemar and Modrzejewska, Zofia and Douglas, Timothy E.L. (2019) The mineralization effect on chitosan hydrogel structure containing collagen and alkaline phosphatase. Journal of Molecular Structure, 1187. pp. 86-97. ISSN 0022-2860
MOLSTRUC_D_18_03618R1_1_.pdf - Accepted Version
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Abstract
Introducing collagen the basic ingredient of bone tissue into the structure of chitosan gels that are formed at physiological body temperature, aims to create so-called biomimetic structures, which are close in composition to the natural composition of bone tissue. The aim of this study was to determine the influence of mineralization on the structural properties of thermosensitive chitosan-collagen gels containing alkaline phosphatase (ALP) by SEM, XRD FTIR and XPS analyses, compared to the previously presented structure of chitosan-collagen gels before mineralization.