cGAS-independent STING activation in response to DNA damage

Unterholzner, Leonie and Dunphy, Gillian (2019) cGAS-independent STING activation in response to DNA damage. Molecular & Cellular Oncology, 6 (4). ISSN 2372-3556

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Official URL: https://doi.org/10.1080/23723556.2018.1558682

Abstract

Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).

Item Type:

Journal Article

Journal or Publication Title:

Molecular & Cellular Oncology

Uncontrolled Keywords:

/dk/atira/pure/subjectarea/asjc/2400

Subjects:

?? IMMUNOLOGY AND MICROBIOLOGY(ALL) ??

Departments:

Faculty of Health and Medicine > Biomedical & Life Sciences

ID Code:

134430

Deposited By:

ep_importer_pure

Deposited On:

22 Jun 2019 08:52

Refereed?:

Yes

Published?:

Published

Last Modified:

21 Sep 2023 02:30

URI:

https://eprints.lancs.ac.uk/id/eprint/134430