cGAS-independent STING activation in response to DNA damage

Unterholzner, Leonie and Dunphy, Gillian (2019) cGAS-independent STING activation in response to DNA damage. Molecular & Cellular Oncology, 6 (4): e1558682. ISSN 2372-3556

Abstract

Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).