cGAS-independent STING activation in response to DNA damage

Unterholzner, Leonie and Dunphy, Gillian (2019) cGAS-independent STING activation in response to DNA damage. Molecular & Cellular Oncology, 6 (4). ISSN 2372-3556

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Abstract

Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).

Item Type:
Journal Article
Journal or Publication Title:
Molecular & Cellular Oncology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2400
Subjects:
ID Code:
134430
Deposited By:
Deposited On:
22 Jun 2019 08:52
Refereed?:
Yes
Published?:
Published
Last Modified:
23 Sep 2020 04:53