Asymmetric aziridine synthesis via aza-Darzens reaction of bromoacylcamphorsultam

Cantrill, Alex A. and Hall, Lee D. and Jarvis, Ashley N. and Osborn, Helen M.I. and Raphy, Jenny and Sweeney, J. B. (1996) Asymmetric aziridine synthesis via aza-Darzens reaction of bromoacylcamphorsultam. Chemical Communications, 1996 (23). pp. 2631-2632. ISSN 1359-7345

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The aza-Darzens reaction of the chiral enolate derived from bromoacetylcamphorsultam 1 with N-(diphenylphosphinyl)aryl- and tert-butyl-methanimines proceeds in good yield to give cis-N-(diphenylphosphinyl)aziridinylcarbonyl sultams with high de. Monochiral cis-aziridinecarboxylates may be obtained in acceptable yield by hydrolysis of these sultams.

Item Type: Journal Article
Journal or Publication Title: Chemical Communications
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2500/2504
ID Code: 133276
Deposited By: ep_importer_pure
Deposited On: 30 Apr 2019 11:25
Refereed?: Yes
Published?: Published
Last Modified: 01 Oct 2019 03:47

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