Reactions of a glycidyl radical equivalent with 2-functionalised allyl stannanes

Baldwin, Jack E. and Adlington, Robert M. and Lowe, Christopher and O'Neil, Ian A. and Sanders, Gillian L. and Schofield, Christopher J. and Sweeney, Joseph B. (1988) Reactions of a glycidyl radical equivalent with 2-functionalised allyl stannanes. Journal of the Chemical Society, Chemical Communications (15). pp. 1030-1031. ISSN 0022-4936

Abstract

Reaction of 2-bromo-N-benzoylglycine methyl ester with 2-functionalised allyl stannane reagents under radical conditions provides a new route to α-alkylated amino acids in good yield, as exemplified by the facile synthesis of 4-methylene glutamate.