Controlled release of chlorhexidine diacetate from a porous methacrylate system:Supercritical fluid assisted foaming and impregnation

Gong, K. and Braden, M. and Patel, M.P. and Rehman, I.U. and Zhang, Z. and Darr, J.A. (2007) Controlled release of chlorhexidine diacetate from a porous methacrylate system:Supercritical fluid assisted foaming and impregnation. Journal of Pharmaceutical Sciences, 96 (8). pp. 2048-2056. ISSN 0022-3549

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Abstract

The release of chlorhexidine diacetate (CX) from a self-curing polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CX-PEM/THFM drug release system. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Pharmaceutical Sciences
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000/3003
Subjects:
ID Code:
132866
Deposited By:
Deposited On:
16 Apr 2019 14:50
Refereed?:
Yes
Published?:
Published
Last Modified:
09 Sep 2020 05:55