Gong, K. and Braden, M. and Patel, M.P. and Rehman, I.U. and Zhang, Z. and Darr, J.A. (2007) Controlled release of chlorhexidine diacetate from a porous methacrylate system : Supercritical fluid assisted foaming and impregnation. Journal of Pharmaceutical Sciences, 96 (8). pp. 2048-2056. ISSN 0022-3549
Full text not available from this repository.Abstract
The release of chlorhexidine diacetate (CX) from a self-curing polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CX-PEM/THFM drug release system. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association.