Notch Signalling as a Therapeutic Target in Cancer

Martinas, Ioana and Parkin, Edward Thomas (2016) Notch Signalling as a Therapeutic Target in Cancer. International Journal of Cancer Therapy and Oncology, 4 (4). ISSN 2330-4049

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Abstract

Notch signalling is a conserved developmental pathway involved, inter alia, in cell-fate decision, morphogenesis and tissue patterning. Extensive research has linked this pathways with a variety of malignancies, cancer stem cell renewal, induction of epithelial-to-mesenchymal transition and tumor angiogenesis. These data indicate that Notch can act as both a tumor suppressor and an oncoprotein, depending upon cellular context and identify it as a potential therapeutic target in cancer treatment. This review discusses the implications of Notch in a number of hematologic and solid malignancies and some of the currently available inhibitors developed against this pathway as potential cancer therapeutics.

Item Type:
Journal Article
Journal or Publication Title:
International Journal of Cancer Therapy and Oncology
Subjects:
ID Code:
125486
Deposited By:
Deposited On:
24 May 2018 15:10
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Oct 2020 02:36