Control of innate-like B cell location for compartmentalised IgM production

Jackson-Jones, Lucy H and Bénézech, Cécile (2018) Control of innate-like B cell location for compartmentalised IgM production. Current opinion in immunology, 50. pp. 9-13. ISSN 0952-7915

Abstract

Natural IgM are crucial for early protection against infection and play an important homeostatic function by clearing dead cells. The production of IgM is ensured by a population of B cells with innate-like properties: their response is rapidly activated by innate signals early during the onset of infection. The main reservoir of innate-like B cells (IBCs) are the serous cavities, but their maintenance and activation depends on their relocation to a variety of lymphoid tissues. Recent advances indicate that fat-associated lymphoid clusters (FALCs) and milky spots contribute to local IgM secretion and play a central role in the localisation and regulation of IBC function.