Does phosphoenolpyruvate carboxykinase have a role in both amino acid and carbohydrate metabolism?

Lea, P. J. and Chen, Z.-H. and Leegood, R. C. and Walker, R. P. (2001) Does phosphoenolpyruvate carboxykinase have a role in both amino acid and carbohydrate metabolism? Amino Acids, 20 (3). pp. 225-241. ISSN 0939-4451

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Abstract

Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the reversible decarboxylation of oxaloacetate to yield phosphoenolpyruvate and CO2. The role of the enzyme in gluconeogenesis and anaplerotic reactions in a range of organisms is discussed, along with the important function in C4 and CAM photosynthesis in higher plants. In addition, new data are presented indicating that PEPCK may play a key role in amino acid metabolism. It is proposed that PEPCK is involved in the conversion of the carbon skeleton of asparagine/aspartate (oxaloacetate) to that of glutamate/glutamine (2-oxoglutarate). This metabolism is particularly important in the transport system, seeds and fruits of higher plants.

Item Type:
Journal Article
Journal or Publication Title:
Amino Acids
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1303
Subjects:
?? amino acid metabolism - asparagine - glutamate - higher plants - oxaloacetate - phosphoenolpyruvate carboxykinasebiochemistryorganic chemistryclinical biochemistryqh301 biology ??
ID Code:
10800
Deposited By:
Deposited On:
24 Jul 2008 10:58
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 09:18