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Relation between selectivity and conductivity in narrow ion channels

Luchinsky, D. G. and Gibby, W. A.T. and Kaufman, I. Kh and McClintock, P. V.E. and Timucin, D. A. (2017) Relation between selectivity and conductivity in narrow ion channels. In: 2017 International Conference on Noise and Fluctuations, ICNF 2017 :. Institute of Electrical and Electronics Engineers Inc.. ISBN 9781509027613

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    Abstract

    To establish the general statistical mechanical properties of highly conductive but selective nano-filters we develop an equilibrium statistical-mechanical theory of the KcsA filter, find the probabilities for the filter to bind ions from the mixed intra- and extra-cellular solutions, and evaluate the conductivity of the filter in its linear response regime. The results provide first principles analytical resolution of the long-standing paradox - how can narrow filter conduct potassium ions at nearly the rate of free diffusion while strongly selecting them over sodium ions - and are applicable to a wide range of biological and artificial channels.

    Item Type: Contribution in Book/Report/Proceedings
    Additional Information: ©2017 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
    Uncontrolled Keywords: conductivity ; generalized Einstein relations ; grand canonical ensemble ; ion channel ; linear response ; selectivity
    Subjects:
    Departments: Faculty of Science and Technology > Physics
    ID Code: 88071
    Deposited By: ep_importer_pure
    Deposited On: 23 Oct 2017 12:04
    Refereed?: No
    Published?: Published
    Last Modified: 19 Jun 2018 01:16
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/88071

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