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The stationary distribution of allele frequencies when selection acts at unlinked loci.

Fearnhead, Paul (2006) The stationary distribution of allele frequencies when selection acts at unlinked loci. Theoretical Population Biology, 70 (3). pp. 376-386.

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    Abstract

    We consider population genetics models where selection acts at a set of unlinked loci. It is known that if the fitness of an individual is multiplicative across loci, then these loci are independent. We consider general selection models, but assume parent-independent mutation at each locus. For such a model, the joint stationary distribution of allele frequencies is proportional to the stationary distribution under neutrality multiplied by a known function of the mean fitness of the population. We further show how knowledge of this stationary distribution enables direct simulation of the genealogy of a sample at a single-locus. For a specific selection model appropriate for complex disease genes, we use simulation to determine what features of the genealogy differ between our general selection model and a multiplicative model.

    Item Type: Article
    Journal or Publication Title: Theoretical Population Biology
    Subjects: Q Science > QA Mathematics
    Departments: Faculty of Science and Technology > Mathematics and Statistics
    ID Code: 8188
    Deposited By: Prof Paul Fearnhead
    Deposited On: 15 Apr 2008 11:21
    Refereed?: Yes
    Published?: Published
    Last Modified: 09 Oct 2013 15:41
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/8188

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