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On the Choice of Genetic Distance in Spatial-Genetic Studies.

Fearnhead, P (2007) On the Choice of Genetic Distance in Spatial-Genetic Studies. Genetics, 177. pp. 427-434. ISSN 1943-2631

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    We look at how to choose genetic distance so as to maximise the power of detecting spatial structure. We answer this question through analysin g two population genetic models that allow for a spatially structured population in a continuous habitat. These models, like most that incorporate spatial s tructure, can be characterised by a separation of time scales: the history of the sample can be split into a scattering and collecting phase, and it is only during the scattering phase that the spatial locations of the sample affects the coalescence times. Our results suggest that the optimal choice of genetic distance is based upon splitting a DNA sequence into segments, and counting the number of segments at which two sequences differ. The size of these segments depends on the length of the scattering phase for the population genetic model.

    Item Type: Journal Article
    Journal or Publication Title: Genetics
    Departments: Faculty of Science and Technology > Mathematics and Statistics
    ID Code: 744
    Deposited By: Prof Paul Fearnhead
    Deposited On: 08 Nov 2007
    Refereed?: Yes
    Published?: Published
    Last Modified: 20 Mar 2019 00:34
    Identification Number:

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