Ikeda, S and Tokuda, T and Yanagisawa, N and Kametani, F and Ohshima, T and Allsop, D (1994) Variability of β-amyloid protein deposited lesions in Down's syndrome brains. The Tohoku journal of experimental medicine, 174 (3). pp. 189-198. ISSN 0040-8727
Full text not available from this repository.Abstract
An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | The Tohoku journal of experimental medicine |
| Uncontrolled Keywords: | Adult ; Alzheimer Disease ; Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Brain ; Brain Chemistry ; Cerebral Amyloid Angiopathy ; Down Syndrome ; Female ; Humans ; Immunoenzyme Techniques ; Male ; Middle Aged ; Nerve Degeneration ; Nerve Tissue Proteins ; Neurites ; Neurofibrillary Tangles ; Peptide Fragments ; RNA Splicing ; tau Proteins |
| Subjects: | UNSPECIFIED |
| Departments: | Faculty of Health and Medicine > Biomedical & Life Sciences |
| ID Code: | 50838 |
| Deposited By: | ep_importer_pure |
| Deposited On: | 07 Nov 2011 16:39 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Jul 2012 19:43 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/50838 |
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