George, A. J. T. and Titus, J. A. and Jost, C. R. and Kurucz, I. and Perez, P. and Andrew, S. M. and Nicholls, P. J. and Huston, J. S. and Segal, D. M. (1995) Redirection of cellular cytotoxicity: a two step approach using recombinant single-chain Fv molecules. Cell Biochemistry and Biophysics, 26 (3). pp. 153-165. ISSN 1085-9195Full text not available from this repository.
In this article the authors discuss an indirect system for redirecting cellular cytotoxicity, which utilizes a “universal” bispecific antibody to redirect T-cells to kill cells targeted with single-chain Fv (sFv) fusion proteins that carry a peptide tag recognized by the bispecific antibody. This approach has a number of theoretical advantages in the immunotherapy of cancer.
|Journal or Publication Title:||Cell Biochemistry and Biophysics|
|Uncontrolled Keywords:||Bispecific antibody - single-chain Fv - redirected cellular cytotoxicity - immunotherapy|
|Subjects:||G Geography. Anthropology. Recreation > GE Environmental Sciences|
|Departments:||Faculty of Science and Technology > Lancaster Environment Centre|
Faculty of Health and Medicine > Health Research
|Deposited On:||06 Feb 2009 15:23|
|Last Modified:||26 Jul 2012 15:58|
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