Lancaster EPrints

Redirection of cellular cytotoxicity: a two step approach using recombinant single-chain Fv molecules.

George, A. J. T. and Titus, J. A. and Jost, C. R. and Kurucz, I. and Perez, P. and Andrew, S. M. and Nicholls, P. J. and Huston, J. S. and Segal, D. M. (1995) Redirection of cellular cytotoxicity: a two step approach using recombinant single-chain Fv molecules. Cell Biochemistry and Biophysics, 26 (3). pp. 153-165. ISSN 1085-9195

Full text not available from this repository.

Abstract

In this article the authors discuss an indirect system for redirecting cellular cytotoxicity, which utilizes a “universal” bispecific antibody to redirect T-cells to kill cells targeted with single-chain Fv (sFv) fusion proteins that carry a peptide tag recognized by the bispecific antibody. This approach has a number of theoretical advantages in the immunotherapy of cancer.

Item Type: Article
Journal or Publication Title: Cell Biochemistry and Biophysics
Uncontrolled Keywords: Bispecific antibody - single-chain Fv - redirected cellular cytotoxicity - immunotherapy
Subjects: G Geography. Anthropology. Recreation > GE Environmental Sciences
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Health Research
ID Code: 22265
Deposited By: ep_ss_importer
Deposited On: 06 Feb 2009 15:23
Refereed?: No
Published?: Published
Last Modified: 26 Jul 2012 15:58
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/22265

Actions (login required)

View Item