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Control of innate-like B cell location for compartmentalised IgM production

Jackson-Jones, Lucy H and Bénézech, Cécile (2018) Control of innate-like B cell location for compartmentalised IgM production. Current opinion in immunology, 50. pp. 9-13. ISSN 0952-7915

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Abstract

Natural IgM are crucial for early protection against infection and play an important homeostatic function by clearing dead cells. The production of IgM is ensured by a population of B cells with innate-like properties: their response is rapidly activated by innate signals early during the onset of infection. The main reservoir of innate-like B cells (IBCs) are the serous cavities, but their maintenance and activation depends on their relocation to a variety of lymphoid tissues. Recent advances indicate that fat-associated lymphoid clusters (FALCs) and milky spots contribute to local IgM secretion and play a central role in the localisation and regulation of IBC function.

Item Type: Journal Article
Journal or Publication Title: Current opinion in immunology
Additional Information: Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 125019
Deposited By: ep_importer_pure
Deposited On: 23 May 2018 08:54
Refereed?: Yes
Published?: Published
Last Modified: 18 Sep 2018 06:12
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/125019

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