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Does phosphoenolpyruvate carboxykinase have a role in both amino acid and carbohydrate metabolism?

Lea, P. J. and Chen, Z.-H. and Leegood, R. C. and Walker, R. P. (2001) Does phosphoenolpyruvate carboxykinase have a role in both amino acid and carbohydrate metabolism? Amino Acids, 20 (3). pp. 225-241. ISSN 0939-4451

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Abstract

Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the reversible decarboxylation of oxaloacetate to yield phosphoenolpyruvate and CO2. The role of the enzyme in gluconeogenesis and anaplerotic reactions in a range of organisms is discussed, along with the important function in C4 and CAM photosynthesis in higher plants. In addition, new data are presented indicating that PEPCK may play a key role in amino acid metabolism. It is proposed that PEPCK is involved in the conversion of the carbon skeleton of asparagine/aspartate (oxaloacetate) to that of glutamate/glutamine (2-oxoglutarate). This metabolism is particularly important in the transport system, seeds and fruits of higher plants.

Item Type: Article
Journal or Publication Title: Amino Acids
Uncontrolled Keywords: Amino acid metabolism - Asparagine - Glutamate - Higher plants - Oxaloacetate - Phosphoenolpyruvate carboxykinase
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
ID Code: 10800
Deposited By: Mr Richard Ingham
Deposited On: 24 Jul 2008 11:58
Refereed?: Yes
Published?: Published
Last Modified: 18 Sep 2013 15:58
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/10800

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