Items where Author is "Soares, Pedro"

Journal Article

Soares, Pedro and Gadd, Morgan S and Frost, Julianty and Galdeano, Carles and Ellis, Lucy and Epemolu, Ola and Rocha, Sonia and Read, Kevin D and Ciulli, Alessio (2018) Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase : Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298). Journal of Medicinal Chemistry, 61 (2). pp. 599-618. ISSN 0022-2623

Frost, Julianty and Galdeano, Carles and Soares, Pedro and Gadd, Morgan S and Grzes, Katarzyna M and Ellis, Lucy and Epemolu, Ola and Shimamura, Satoko and Bantscheff, Marcus and Grandi, Paola and Read, Kevin D and Cantrell, Doreen A and Rocha, Sonia and Ciulli, Alessio (2016) Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nature Communications, 7: 13312. ISSN 2041-1723

Galdeano, Carles and Gadd, Morgan Stuart and Soares, Pedro and Scaffidi, Salvatore and van Molle, Inge and Birced, Ipek and Hewitt, Sarah and Dias, David M and Ciulli, Alessio (2014) Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. Journal of Medicinal Chemistry, 57 (20). pp. 8657-8663. ISSN 0022-2623