Items where Author is "Parkin, Edward"

Bryers, Amelia and Hawkes, Cheryl A and Parkin, Edward and Dawson, Neil (2024) Progress towards understanding risk factor mechanisms in the development of autism spectrum disorders. Biochemical Society Transactions, 52 (5). pp. 2047-2058. ISSN 0300-5127

Armstrong, Paul and Güngör, Hüseyin and Anongjanya, Pariya and Tweedy, Clare and Parkin, Edward and Johnston, Jamie and Carr, Ian M and Dawson, Neil and Clapcote, Steven J (2024) Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease. Neuropsychopharmacology, 49 (10). pp. 1559-1568. ISSN 0893-133X

Reich, Niklas and Parkin, Edward and Dawson, Neil (2024) Liposome nanoparticle conjugation and cell penetrating peptide sequences ( CPPs ) enhance the cellular delivery of the tau aggregation inhibitor RI ‐ AG03. Journal of Cellular and Molecular Medicine, 28 (11): e18477. ISSN 1582-1838

Marshall, Toby and Benson, Fiona and Parkin, Edward and Fullwood, Nigel and Allsop, David (2024) Purification of the neurodegenerative disease associated protein TDP-43 and development of TDP-43 aggregation inhibitors. PhD thesis, Lancaster University.

Reich, Niklas and Dawson, Neil and Parkin, Edward (2023) Investigation of a Tau aggregation inhibitor peptide and peptide-conjugated liposomes as a potential treatment for Alzheimer’s Disease. PhD thesis, Lancaster University.

Hammond, Jessica and Allsop, David and Parkin, Edward (2023) Air pollution, nanotoxicity and neurodegeneration; exploring the relationship between environmental metallic nanoparticles and human health. PhD thesis, Lancaster University.

Owens, Lauren and Parkin, Edward and Benedetto, Alexandre and Gaffney, Christopher and Dawson, Neil (2023) The Role of Fibrates and Soluble Amyloid Precursor Alpha in Alzheimer’s Disease and Longevity. PhD thesis, Lancaster University.

Bracewell, Joshua and Parkin, Edward (2023) The significance of sAPPα production to increase cell viability in Alzheimer’s disease cell models. Masters thesis, Lancaster University.

Owens, Lauren and Bracewell, Joshua and Benedetto, Alex and Dawson, Neil and Gaffney, Christopher and Parkin, Edward (2022) BACE1 Overexpression Reduces SH-SY5Y Cell Viability Through a Mechanism Distinct from Amyloid-β Peptide Accumulation : Beta Prime-Mediated Competitive Depletion of sAβPPα. Journal of Alzheimer's Disease, 86 (3). pp. 1201-1220. ISSN 1387-2877

Sultan, Fatima and Parkin, Edward (2022) The Amyloid Precursor Protein Plays Differential Roles in the UVA Resistance and Proliferation of Human Retinal Pigment Epithelial Cells. Protein and Peptide Letters, 29 (4). pp. 313-327. ISSN 0929-8665

Sultan, Fatima and Parkin, Edward (2022) Characterising the role of the Amyloid Precursor Protein and Glucagon-like peptide-1 analogues in Age-Related Macular Degeneration. Masters thesis, Lancaster University.

Owens, Lauren and Benedetto, Alex and Dawson, Neil and Gaffney, Christopher and Parkin, Edward (2021) Gene therapy-mediated enhancement of protective protein expression for the treatment of Alzheimer's disease. Brain Research, 1753: 147264. ISSN 0006-8993

Simmons, Hannah and Parkin, Edward (2019) Determining the mechanism of dichloroacetate-regulated processing of the Alzheimer’s disease-related amyloid precursor protein. Masters thesis, Lancaster University.

Holmes, Sophie and Parkin, Edward (2018) The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on cell viability, ADAM10 maturation and the proteolysis of ADAM10 substrates in SH-SY5Y cells. PhD thesis, Lancaster University.

Obasse, Idira Christopher and Allsop, David and Parkin, Edward (2017) Developing peptide-based inhibitors of amylin aggregation as a novel treatment for type 2 diabetes. PhD thesis, Lancaster University.

Hammond, Jessica and Parkin, Edward (2016) Sodium dichloroacetate (DCA) impairs β-secretase-mediated proteolysis of the alzheimer's disease amyloid precursor protein (APP). Masters thesis, Lancaster University.

Hammond, Jessica and Parkin, Edward (2016) Sodium dichloroacetate (DCA) impairs β-secretase-mediated proteolysis of the alzheimer's disease amyloid precursor protein (APP). Masters thesis, Lancaster University.

Gough, Mallory and Delury, Craig and Parkin, Edward (2015) The E1 copper binding domain of full-length amyloid precursor protein promotes epithelial to mesenchymal transition in DU145 cells in isoform-specific manner. International Journal of Biochemistry Research and Review, 6 (1). pp. 264-273. ISSN 2231-086X

Blanthorn-Hazell, Sophee and Parkin, Edward (2015) The role of the E2 copper binding domain in the cell biology of the amyloid precursor protein. Masters thesis, Lancaster University.

Gough, Mallory and Blanthorn-Hazell, Sophee and Delury, Craig and Parkin, Edward (2014) The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells. Biochemical and Biophysical Research Communications, 453 (4). pp. 741-747. ISSN 0006-291X

Delury, Craig and Tinker, Claire and Rivers, Samantha and Hodges, Matt and Broughton, Susan and Parkin, Edward (2013) Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1. International Journal of Biochemistry Research and Review, 3 (4). pp. 278-290. ISSN 2231-086X

Gough, Mallory and Parr-Sturgess, Catherine and Parkin, Edward (2011) Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease. Biochemistry Research International, 2011: 721463. ISSN 2090-2255

Taylor, Mark and Moore, Susan and Mayes, Jennifer and Parkin, Edward and Beeg, Marten and Canovi, Mara and Gobbi, Marco and Mann, David M A and Allsop, David (2010) Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's disease. Biochemistry, 49 (15). pp. 3261-3272. ISSN 1520-4995

Harris, Benjamin and Pereira, Isabel and Parkin, Edward (2009) Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein. Brain Research, 1296 (n/a). pp. 203-215.

Parkin, Edward and Harris, Benjamin (2009) A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10. Journal of Neurochemistry, 108 (6). pp. 1464-1479. ISSN 1471-4159

Parkin, Edward (2008) Alpha-Secretase and Alzheimer's disease. In: Recent advances in the biology of secretases, key proteases in Alzheimer's disease :. Research Signpost, pp. 183-211. ISBN 978-81-308-0263-3

Parkin, Edward and Turner, Anthony and Hooper, Nigel (1999) Distribution of presenilins and amyloid precursor protein in detergent-insoluble membrane microdomains. In: Alzheimer's disease : methods and protocols. Humana Press, pp. 345-360. ISBN 978-0896037373

Parkin, Edward and Hussain, I and Turner, A J and Hooper, N M (1997) The amyloid precursor protein is not enriched in caveolae-like, detergent-insoluble membrane microdomains. Journal of Neurochemistry, 69 (5). pp. 2179-2188. ISSN 0022-3042

Parkin, Edward and Turner, A J and Hooper, N M (1996) A role for calcium and annexins in the formation of caveolae. Biochemical Society Transactions, 24 (3). 444S. ISSN 0300-5127

Turner, Anthony and Parkin, Edward and Hooper, Nigel (1996) Glycosylation and glycosylphosphatidylinositol membrane anchors. In: Regulatory protein modification : techniques and protocols. Humana Press, pp. 395-427. ISBN 9780896034150

Parkin, Edward and Turner, A J and Hooper, N M (1996) Isolation and characterization of two distinct low-density, Triton-insoluble, complexes from porcine lung membranes. Biochemical Journal, 319 (3). pp. 887-896. ISSN 0264-6021

Parkin, Edward and Rolph, Carole (1995) Phoshatidylcholine biosynthesis and cell growth in Apium graveolens. Physiologia Plantarum, 94 (4). pp. 643-650. ISSN 0031-9317