Items where Author is "Middleton, David"

Journal Article

Middleton, David (2025) Conformational Analysis of Uniformly 13C-Labeled Peptides by Rotationally Selected 13Cα-13CH3 Double-Quantum Solid-State NMR. Molecules, 30 (3): 739. ISSN 1420-3049

Whitehead, Meredith and Yusoff, Syabira and Ahmad, Sadia and Schmidt, Lukas and Mayr, Manuel and Madine, Jillian and Middleton, David and Shanahan, Catherine (2023) Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization. Aging Cell, 22 (2): e13746. ISSN 1474-9718

Lau, Sophie and Middleton, David (2022) Analysis of the orientation of cholesterol in high-density lipoprotein nanodiscs using solid-state NMR. Physical Chemistry Chemical Physics, 24: 23651. ISSN 1463-9076

Mapley, Bethany and Townsend, David and Griffin, John and Ashton, Lorna and Middleton, David (2021) 19F Solid-State NMR and Vibrational Raman Characterization of Corticosteroid Drug-Lipid Membrane Interactions. ChemPlusChem, 86 (11). pp. 1517-1523. ISSN 2192-6506

Townsend, David and Middleton, David and Ashton, Lorna (2020) Raman Spectroscopy with 2D Perturbation Correlation Moving Windows for the Characterization of Heparin–Amyloid Interactions. Analytical Chemistry, 92 (20). 13822–13828. ISSN 0003-2700

Lau, Sophie and Middleton, David (2020) Sensitive morphological characterization of oriented high‐density lipoprotein nanoparticles using 31P NMR spectroscopy. Angewandte Chemie International Edition, 59 (41). pp. 18126-18130. ISSN 1433-7851

Townsend, David and Fullwood, Nigel and Yates, Edwin and Middleton, David (2020) Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin. Biochemistry. ISSN 0006-2960

Middleton, David and Townsend, David and Hughes, Eleri and Fullwood, Nigel and Siligardi, Giuliano and Hussain, Rohanah and Mala, Bara (2020) Circular dichroism spectroscopy identifies the β-adrenoceptor agonist salbutamol as a direct inhibitor of tau filament formation in vitro. ACS Chemical Neuroscience. ISSN 1948-7193

Lau, Sophie and Griffin, John and Hughes, Eleri and Middleton, David (2019) Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR. Chemical Communications, 55 (88). pp. 13287-13290. ISSN 1359-7345

Davies, Hannah and Madine, Jillian and Middleton, David (2015) Comparisons with amyloid-β reveal an aspartate residue that stabilizes fibrils of the aortic amyloid peptide medin. Journal of Biological Chemistry, 290. pp. 7791-7803. ISSN 0021-9258

Whittaker, Christopher and Patching, Simon and Esmann, Mikael and Middleton, David (2015) Ligand orientation in a membrane-embedded receptor site revealed by solid-state NMR with paramagnetic relaxation enhancement. Organic and Biomolecular Chemistry, 13 (9). pp. 2664-2668. ISSN 1477-0520

Thesis

Lau, Sophie and Middleton, David and Anwar, Jamshed (2021) The Structure-Function Relationship of Atheroprotective ApoA-I Mutants in High-Density Lipoproteins. PhD thesis, Lancaster University.

Ettah, Ilokugbe and Ashton, Lorna and Dalby, Paul and Middleton, David (2020) Unravelling the complexities of protein conformational stability using Raman spectroscopy and two-dimensional correlation analysis. PhD thesis, Lancaster University.

Townsend, David John and Middleton, David (2016) Molecular level characterisation of apolipoprotein A-I aggregation leading to fibrils comprising of both α-helical and β-sheet structures. PhD thesis, Lancaster University.