Items where Author is "Jakeman, David L"
McKeown, Brendan T and Relja, Nicholas J and Hall, Steven R and Gebremeskel, Simon and MacLeod, Jeanna M and Veinotte, Chansey J and Bennett, Leah G and Ohlund, Leanne B and Sleno, Lekha and Jakeman, David L and Berman, Jason N and Johnston, Brent and Goralski, Kerry B (2022) Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models. Canadian journal of physiology and pharmacology, 100 (11). pp. 1065-1076. ISSN 0008-4212
Forget, Stephanie M and Robertson, Andrew W and Hall, Steven R and MacLeod, Jeanna M and Overy, David P and Kerr, Russell G and Goralski, Kerry B and Jakeman, David L (2018) Isolation of a jadomycin incorporating L-ornithine, analysis of antimicrobial activity and jadomycin reactive oxygen species (ROS) generation in MDA-MB-231 breast cancer cells. The Journal of antibiotics, 71 (8). pp. 722-730. ISSN 0021-8820
Robertson, Andrew W and MacLeod, Jeanna M and MacIntyre, Logan W and Forget, Stephanie M and Hall, Steven R and Bennett, Leah G and Correa, Hebelin and Kerr, Russell G and Goralski, Kerry B and Jakeman, David L (2018) Post Polyketide Synthase Carbon-Carbon Bond Formation in Type-II PKS-Derived Natural Products from Streptomyces venezuelae. Journal of Organic Chemistry, 83 (4). pp. 1876-1890. ISSN 0022-3263
Hall, Steven R and Toulany, Jay and Bennett, Leah G and Martinez-Farina, Camilo F and Robertson, Andrew W and Jakeman, David L and Goralski, Kerry B (2017) Jadomycins Inhibit Type II Topoisomerases and Promote DNA Damage and Apoptosis in Multidrug-Resistant Triple-Negative Breast Cancer Cells. Journal of Pharmacology and Experimental Therapeutics, 363 (2). pp. 196-210. ISSN 0022-3565
Hall, Steven R and Blundon, Heather L and Ladda, Matthew A and Robertson, Andrew W and Martinez-Farina, Camilo F and Jakeman, David L and Goralski, Kerry B (2015) Jadomycin breast cancer cytotoxicity is mediated by a copper-dependent, reactive oxygen species-inducing mechanism. Pharmacology research & perspectives, 3 (2). e00110. ISSN 2052-1707
Issa, Mark E and Hall, Steven R and Dupuis, Stephanie N and Graham, Cathy L and Jakeman, David L and Goralski, Kerry B (2014) Jadomycins are cytotoxic to ABCB1-, ABCC1-, and ABCG2-overexpressing MCF7 breast cancer cells. Anti-Cancer Drugs, 25 (3). pp. 255-69. ISSN 0959-4973