Items where Author is "Ciulli, Alessio"

Testa, Andrea and Lucas, Xavier and Castro, Guilherme V and Chan, Kwok-Ho and Wright, Jane E and Runcie, Andrew C and Gadd, Morgan S and Harrison, William T A and Ko, Eun-Jung and Fletcher, Daniel and Ciulli, Alessio (2018) 3-Fluoro-4-hydroxyprolines : Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. Journal of the American Chemical Society, 140 (29). pp. 9299-9313. ISSN 0002-7863

Soares, Pedro and Gadd, Morgan S and Frost, Julianty and Galdeano, Carles and Ellis, Lucy and Epemolu, Ola and Rocha, Sonia and Read, Kevin D and Ciulli, Alessio (2018) Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase : Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298). Journal of Medicinal Chemistry, 61 (2). pp. 599-618. ISSN 0022-2623

Cardote, Teresa A F and Gadd, Morgan S and Ciulli, Alessio (2017) Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex. Structure, 25 (6). 901-911.e3. ISSN 0969-2126

Gadd, Morgan S and Testa, Andrea and Lucas, Xavier and Chan, Kwok-Ho and Chen, Wenzhang and Lamont, Douglas J and Zengerle, Michael and Ciulli, Alessio (2017) Structural basis of PROTAC cooperative recognition for selective protein degradation. Nature Chemical Biology, 13 (5). pp. 514-521. ISSN 1552-4450

Frost, Julianty and Galdeano, Carles and Soares, Pedro and Gadd, Morgan S and Grzes, Katarzyna M and Ellis, Lucy and Epemolu, Ola and Shimamura, Satoko and Bantscheff, Marcus and Grandi, Paola and Read, Kevin D and Cantrell, Doreen A and Rocha, Sonia and Ciulli, Alessio (2016) Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nature Communications, 7: 13312. ISSN 2041-1723

Gadd, Morgan Stuart and Bulatov, Emil and Ciulli, Alessio (2015) Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases. PLoS ONE, 10 (6): e0131218. ISSN 1932-6203

Galdeano, Carles and Gadd, Morgan Stuart and Soares, Pedro and Scaffidi, Salvatore and van Molle, Inge and Birced, Ipek and Hewitt, Sarah and Dias, David M and Ciulli, Alessio (2014) Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. Journal of Medicinal Chemistry, 57 (20). pp. 8657-8663. ISSN 0022-2623