Role of Neisseria meningitidis luxS in Cell-to-Cell Signaling and Bacteremic Infection.

Winzer, Klaus and Sun, Yao-hui and Green, Andrew and Delory, Marie and Blackley, David and Hardie, Kim R. and Baldwin, Thomas J. and Tang, Christoph M. (2002) Role of Neisseria meningitidis luxS in Cell-to-Cell Signaling and Bacteremic Infection. Infection and Immunity, 70 (4). pp. 2245-2248. ISSN 0019-9567

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Abstract

Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.

Item Type:
Journal Article
Journal or Publication Title:
Infection and Immunity
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2725
Subjects:
?? infectious diseasesimmunologymicrobiologyparasitologyqh301 biology ??
ID Code:
9551
Deposited By:
Deposited On:
13 Jun 2008 13:15
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 11:41