Angiotensin-converting enzyme as a target for the development of novel insect growth regulators.

Isaac, R. Elwyn and Lamango, Nazarius S. and Ekbote, Uma and Taylor, C. A. and Hurst, Debra and Weaver, Robert J. and Carhan, Ahmet and Burnham, Susan and Shirras, Alan D. (2007) Angiotensin-converting enzyme as a target for the development of novel insect growth regulators. Peptides, 28 (1). pp. 153-162. ISSN 0196-9781

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Abstract

Insect angiotensin converting enzyme (ACE) is a zinc metallopeptidase capable of inactivating a variety of small to medium size peptide hormones by cleavage of C-terminal dipeptides and dipeptideamides. High levels of ACE activity are found in the hemolymph and in reproductive tissues of insects, where the enzyme is considered to have an important role in the metabolism of bioactive peptides. Therefore, inhibiting ACE activity is expected to interfere with the peptidergic endocrine system and to have detrimental effects on growth, development and reproduction. We will review the studies showing that ACE inhibitors do indeed disrupt growth and reproduction in various insect species. We will also present some new genetic and pharmacological data that strengthens our conclusion that ACE should be considered as a potential target for the development of new insect growth regulators.

Item Type:
Journal Article
Journal or Publication Title:
Peptides
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2804
Subjects:
?? insect controlangiotensin-converting enzymereproductionpeptidaseanceace inhibitorscellular and molecular neurosciencebiochemistryendocrinologyphysiologyqh301 biology ??
ID Code:
9401
Deposited By:
Deposited On:
09 Jun 2008 08:21
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 11:39