Plasmodium chabaudi chabaudi AS: modification of acute infection in CBA/Ca mice as a result of pre-treatment with erythrocyte band 3 in adjuvant.

O'Dea, Kieran P. and McKean, Paul G. and Brown, K. Neil (2002) Plasmodium chabaudi chabaudi AS: modification of acute infection in CBA/Ca mice as a result of pre-treatment with erythrocyte band 3 in adjuvant. Experimental Parasitology, 102 (2). pp. 66-71. ISSN 0014-4894

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Abstract

In this paper, in vivo data are presented that suggest a role for host recognition of erythrocyte band 3 in the control of malaria parasitaemia. The course of Plasmodium chabaudi chabaudi AS acute infection in CBA/Ca mice was suppressed or enhanced as a result of treatment on two occasions with enriched preparations of normal erythrocyte band 3 in adjuvant. Co-treatment with band 3 and a recombinant polypeptide encoding the C-terminal region of the P. c. chabaudi AS merozoite surface protein 1, which on its own had no clear effect on parasitaemia, appeared to modulate band 3-induced inhibition. Despite several-fold reductions in ascending parasitaemias in some band 3-immunized groups, there was a lack of obvious or unexpected anaemia prior to, or during infection, indicating a degree of specificity in the parasitaemia modifying response for infected rather than uninfected erythrocytes. These findings support a role for modified host recognition of erythrocyte band 3 in the partial immunity that transcends phenotypic and genotypic antigenic variation by malaria parasites.

Item Type:
Journal Article
Journal or Publication Title:
Experimental Parasitology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2400/2403
Subjects:
?? immunologyparasitologyqh301 biology ??
ID Code:
9240
Deposited By:
Deposited On:
02 Jun 2008 09:59
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 11:38