Short and medium chain length chlorinated paraffins in UK human milk fat

Thomas, Gareth O. and Farrar, David and Braekvelt, Eric and Stern, Gary and Kalantzi, Olga L. and Martin, Francis L. and Jones, Kevin C. (2006) Short and medium chain length chlorinated paraffins in UK human milk fat. Environment International, 32 (1). pp. 34-40. ISSN 0160-4120

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Chlorinated paraffins (also called polychlorinated n-alkanes — PCAs) are a class of industrial chemicals comprising chlorinated straight chain hydrocarbons. They have a wide range of applications and are now found in a range of environmental compartments. We analysed a total of 25 human milk-fat samples, donated by 18 individuals from the urban London and more rural Lancaster areas in the UK, for short chain PCAs (C10–C13 sPCAs) and medium chain PCAs (C14–C17 mPCAs), using gas chromatography–ECNI high-resolution mass spectrometry. Our study confirms that trace quantities of PCAs can reach human milk-fat. sPCAs were detected in all but four samples, while mPCAs were detected in all samples. The median sPCA concentration was 180 ng/g fat (range of 49 to 820 ng/g fat — detected values only) and the median mPCA concentration was 21 ng/g fat (range of 6.2 to 320 ng/g fat). No differences were noted in ranges of observed values for either sPCAs or mPCAs between samples from London and Lancaster. Most samples also exhibited similar patterns of sPCAs and mPCAs. One sample exhibited a different pattern for sPCAs and mPCAs, an observation that may be related to differences in exposure or biological factors for this individual.

Item Type:
Journal Article
Journal or Publication Title:
Environment International
Uncontrolled Keywords:
?? breast-milkorganochlorinesccpmccpgeneral environmental scienceenvironmental science(all)qh301 biology ??
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Deposited On:
28 May 2008 15:56
Last Modified:
16 Jul 2024 08:47