Modulation of intra- and inter-hemispheric connectivity between primary and premotor cortex during speech perception

Nuttall, Helen E and Kennedy-Higgins, Dan and Devlin, Joseph T. and Adank, Patti (2018) Modulation of intra- and inter-hemispheric connectivity between primary and premotor cortex during speech perception. Brain and Language, 187. pp. 74-82. ISSN 0093-934X

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Primary motor (M1) areas for speech production activate during speech perception. It has been suggested that such activation may be dependent upon modulatory inputs from premotor cortex (PMv). If and how PMv differentially modulates M1 activity during perception of speech that is easy or challenging to understand, however, is unclear. This study aimed to test the link between PMv and M1 during challenging speech perception in two experiments. The first experiment investigated intra-hemispheric connectivity between left hemisphere PMv and left M1 lip area during comprehension of speech under clear and distorted listening conditions. Continuous theta burst stimulation (cTBS) was applied to left PMv in eighteen participants (aged 18–35). Post-cTBS, participants performed a sentence verification task on distorted (imprecisely articulated), and clear speech, whilst also undergoing stimulation of the lip representation in the left M1 to elicit motor evoked potentials (MEPs). In a second, separate experiment, we investigated the role of inter-hemispheric connectivity between right hemisphere PMv and left hemisphere M1 lip area. Dual-coil transcranial magnetic stimulation was applied to right PMv and left M1 lip in fifteen participants (aged 18–35). Results indicated that disruption of PMv during speech perception affects comprehension of distorted speech specifically. Furthermore, our data suggest that listening to distorted speech modulates the balance of intra- and inter-hemispheric interactions, with a larger sensorimotor network implicated during comprehension of distorted speech than when speech perception is optimal. The present results further understanding of PMv-M1 interactions during auditory-motor integration.

Item Type:
Journal Article
Journal or Publication Title:
Brain and Language
Additional Information:
This is the author’s version of a work that was accepted for publication in Brain and Language. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Brain and Language, 187, 2018 DOI: 10.1016/j.bandl.2017.12.002
Uncontrolled Keywords:
?? linguistics and languageexperimental and cognitive psychologycognitive neurosciencespeech and hearing ??
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Deposited On:
08 Oct 2018 09:18
Last Modified:
31 Dec 2023 00:53