Therapeutic potential of flavonoids in spinal cord injury

Zhang, Peng and Holscher, Christian and Ma, Xun (2017) Therapeutic potential of flavonoids in spinal cord injury. Reviews in the Neurosciences, 28 (1). pp. 87-101. ISSN 0334-1763

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Spinal cord injury (SCI) is a catastrophic event that can profoundly affect a patient's life, with far-reaching social and economic effects. A consequential sequence of SCI is the significant neurological or psychological deficit, which obviously contributes to the overall burden of this condition. To date, there is no effective treatment for SCI. Therefore, developing novel therapeutic strategies for SCI is highly prioritized. Flavonoids, one of the most numerous and ubiquitous groups of plant metabolites, are the active ingredients of traditional Chinese medicine such as Scutellaria baicalensis Georgi (Huang Qin) or Ginkgo biloba (Ying Xin). Accumulated research data show that flavonoids possess a range of key pharmacological properties such as anti-inflammatory, anti-oxidant, anti-tumor, anti-viral, anti-cardiovascular disease, immunomodulatory, and neuroprotective effects. Based on this, the flavonoids show therapeutic potential for SCI diseases. In this paper, we will review the pharmacological properties of different types of flavonoids for the treatment of SCI diseases, and potential underlying biochemical mechanisms of action will also be described.

Item Type:
Journal Article
Journal or Publication Title:
Reviews in the Neurosciences
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©2017 Walter de Gruyter GmbH, Berlin/Boston.
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Deposited On:
07 Dec 2017 11:46
Last Modified:
11 May 2022 05:40