Anti-Adherent Biomaterials for Prevention of Catheter Biofouling

McCoy, Colin and Irwin, Nicola J. and Donnelly, Louise and Jones, David and Hardy, John George and Carson, Louise (2018) Anti-Adherent Biomaterials for Prevention of Catheter Biofouling. International Journal of Pharmaceutics, 535 (1-2). pp. 420-427. ISSN 0378-5173

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Abstract

Medical device-associated infections present a leading global healthcare challenge, and effective strategies to prevent infections are urgently required. Herein, we present an innovative anti-adherent hydrogel copolymer as a candidate catheter coating with complementary hydrophobic drug-carrying and eluting capacities. The amphiphilic block copolymer, Poloxamer 188, was chemically-derivatized with methacryloyl moieties and copolymerized with the hydrogel monomer, 2-hydroxyethyl methacrylate. Performance of the synthesized copolymers was evaluated in terms of equilibrium swelling, surface water wettability, mechanical integrity, resistance to encrustation and bacterial adherence, and ability to control release of the loaded fluoroquinolone antibiotic, ofloxacin. The developed matrices were able to provide significant protection from fouling, with observed reductions of over 90% in both adherence of the common urinary pathogen Escherichia coli and encrusting crystalline deposits of calcium and magnesium salts relative to the commonly employed hydrogel, poly (hydroxyethyl methacrylate). Additionally, the release kinetics of a loaded hydrophobic drug could be readily tuned through facile manipulation of polymer composition. This combinatorial approach shows significant promise in the development of suitable systems for prevention of catheter-associated infections.

Item Type:
Journal Article
Journal or Publication Title:
International Journal of Pharmaceutics
Additional Information:
This is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, 535, 1-2, 2018 DOI: 10.1016/j.ijpharm.2017.11.043
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000/3003
Subjects:
ID Code:
88971
Deposited By:
Deposited On:
02 Jan 2018 09:58
Refereed?:
Yes
Published?:
Published
Last Modified:
23 Sep 2020 03:52