Photochemically controlled drug dosing from a polymeric scaffold

Donnelly, Louise and Hardy, John George and Gorman, Sean P. and Jones, David S. and Irwin, Nicola J. and McCoy, Colin P. (2017) Photochemically controlled drug dosing from a polymeric scaffold. Pharmaceutical Research, 34 (7). pp. 1469-1476. ISSN 0724-8741

[img]
Preview
PDF (044 - Pharm Res - 2017 - NSAIDS)
044_Pharm_Res_2017_NSAIDS.pdf - Published Version
Available under License Creative Commons Attribution.

Download (595kB)

Abstract

Purpose To develop the first photoactive biomaterial coating capable of controlled drug dosing via inclusion of synthesised drug-3,5-dimethoxybenzoin (DMB) conjugates in a poly(2-methyoxyethyl acrylate) (pMEA) scaffold. Methods Flurbiprofen- and naproxen-DMB conjugates were prepared via esterification and characterised via NMR spectroscopy and mass spectrometry following chromatographic purification. Conjugate photolysis was investigated in acetonitrile solution and within the pMEA matrix following exposure to low-power 365 nm irradiation. Photo-liberation of drug from pMEA into phosphate buffered saline was monitored using UV-vis spectroscopy. Results The synthetic procedures yielded the desired drug conjugates with full supporting characterisation. Drug regeneration through photolysis of the synthesised conjugates was successful in both acetonitrile solution and within the pMEA scaffold upon UV irradiation. Conjugates were retained within the pMEA scaffold with exclusive drug liberation following irradiation and increased drug dose with increasing exposure. Multi-dosing capacity was demonstrated though the ability of successive irradiation periods to generate further bursts of drug. Conclusion This study demonstrates the first application of photochemically controlled drug release from a biomaterial coating and the feasibility of using pMEA as a scaffold for housing the photoactive drug-DMB conjugates.

Item Type:
Journal Article
Journal or Publication Title:
Pharmaceutical Research
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2736
Subjects:
ID Code:
88575
Deposited By:
Deposited On:
06 Nov 2017 09:42
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Dec 2020 05:07