α-Synuclein and the pathogenesis of Parkinson’s disease.

Martin, Frank and Allsop, David and Williamson, Sally J. M. and Paleologou, Katerina E. and El-Agnaf, Omar M. A. (2004) α-Synuclein and the pathogenesis of Parkinson’s disease. Protein and Peptide Letters, 11 (3). pp. 229-237. ISSN 0929-8665

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Abstract

Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson’s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

Item Type:
Journal Article
Journal or Publication Title:
Protein and Peptide Letters
Uncontrolled Keywords:
/dk/atira/pure/researchoutput/libraryofcongress/qh301
Subjects:
ID Code:
8845
Deposited By:
Deposited On:
15 May 2008 10:46
Refereed?:
Yes
Published?:
Published
Last Modified:
26 May 2020 02:22