Chiral catenanes and rotaxanes:fundamentals and emerging applications

Evans, Nicholas Henley (2018) Chiral catenanes and rotaxanes:fundamentals and emerging applications. Chemistry - A European Journal, 24 (13). pp. 3101-3112. ISSN 0947-6539

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Molecular chirality provides a key challenge in host-guest recognition and other related chemical applications such as asymmetric catalysis. For a molecule to act as an efficient enantioselective receptor, it requires multi-point interactions between host and chiral guest, which may be achieved by an appropriate chiral 3D scaffold. As a consequence of their interlocked structure, catenanes and rotaxanes may present such a 3D scaffold, and can be chiral by inclusion of a classical chiral element and/or as a consequence of the mechanical bond. This Minireview presents illustrative examples of chiral [2]catenanes and [2]rotaxanes, and discusses where these molecules have been used in chemical applications such as chiral host-guest recognition and asymmetric catalysis.

Item Type:
Journal Article
Journal or Publication Title:
Chemistry - A European Journal
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This is the peer reviewed version of the following article: N. H. Evans, Chem. Eur. J. 2018, 24, 3101 which has been published in final form at This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
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19 Oct 2017 07:56
Last Modified:
16 Sep 2023 01:35