Characterization of the metabolically healthy phenotype in overweight and obese British men

Ingle, Lee and Swainson, Michelle and Brodie, David and Sandercock, Gavin R (2017) Characterization of the metabolically healthy phenotype in overweight and obese British men. Preventive Medicine, 94. pp. 7-11. ISSN 0091-7435

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We calculated the prevalence of the metabolically healthy but obese (MHO) phenotype in (n = 9177) British men (age 48.9 ± 7.4 years) attending preventive health screening between 2000 and 2009. We examined differences in cardiorespiratory fitness (Fitness) and self-reported physical activity levels, according to whether the men were metabolically healthy (< 2 components of the metabolic syndrome), and by BMI category (normal-weight, overweight, obese). Fitness was estimated from treadmill exercise as VO2peak and classified as: Low, Moderate, or High using age-specific cut-offs. We identified 21.6% of our sample as obese, of whom 83.1% were metabolically healthy. Compared with the metabolic unhealthy obese (MUO; 3.7% of sample), MHO phenotypes were fitter (effect size d = 0.21) and were more physically active (d = 0.31). Logistic regression showed high fitness (OR = 2.40, 95% CI 1.38–4.19), and being physically active (OR = 1.71, 95% CI 1.14–2.56) to be independently associated with the MHO phenotype. Our findings agree with US data suggesting that higher cardiorespiratory fitness is a characteristic of the MHO phenotype. Our finding that meeting physical activity guidelines was associated with the MHO phenotype independent of fitness is, however, novel. If confirmed, our findings indicate that public health messages that encourage active lifestyles to promote fitness should be encouraged regardless of weight status.

Item Type:
Journal Article
Journal or Publication Title:
Preventive Medicine
Additional Information:
This is the author’s version of a work that was accepted for publication in Preventive Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Preventive Medicine, 94, 2017 DOI: 10.1016/j.ypmed.2016.11.001
Uncontrolled Keywords:
?? cardiorespiratory fitnessphysical activitymetabolic healthymetabolic unhealthyobesity metabolic syndromepublic health, environmental and occupational healthepidemiology ??
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Deposited On:
05 Sep 2017 10:42
Last Modified:
31 Dec 2023 00:50