Influenza vaccination for immunocompromised patients: summary of a systematic review and meta-analysis.

Beck, Charles R. and Isba, Rachel Elizabeth (2013) Influenza vaccination for immunocompromised patients: summary of a systematic review and meta-analysis. Influenza and Other Respiratory Viruses, 7 (Suppl.). pp. 72-75. ISSN 1750-2640

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Abstract

Vaccination of immunocompromised patients is recommended in many national guidelines to protect against severe or complicated influenza infection. However, due to uncertainties over the evidence base, implementation is frequently patchy and dependent on individual clinical discretion. We conducted a systematic review and meta-analysis to assess the evidence for influenza vaccination in this patient group. Healthcare databases and grey literature were searched and screened for eligibility. Data extraction and assessments of risk of bias were undertaken in duplicate, and results were synthesised narratively and using meta-analysis where possible. Our data show that whilst the serological response following vaccination of immunocompromised patients is less vigorous than in healthy controls, clinical protection is still meaningful, with only mild variation in adverse events between aetiological groups. Although we encountered significant clinical and statistical heterogeneity in many of our meta-analyses, we advocate that immunocompromised patients should be targeted for influenza vaccination.

Item Type:
Journal Article
Journal or Publication Title:
Influenza and Other Respiratory Viruses
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2740
Subjects:
ID Code:
87070
Deposited By:
Deposited On:
17 Jul 2017 12:30
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jan 2020 10:24