The impact of diet-based glycaemic response and glucose regulation on cognition:evidence across the lifespan

Sünram-Lea, Sandra I. and Owen, Lauren (2017) The impact of diet-based glycaemic response and glucose regulation on cognition:evidence across the lifespan. Proceedings of the Nutrition Society, 76 (4). pp. 466-477. ISSN 0029-6651

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Abstract

The brain has a high metabolic rate and its metabolism is almost entirely restricted to oxidative utilisation of glucose. These factors emphasise the extreme dependence of neural tissue on a stable and adequate supply of glucose. Whereas initially it was thought that only glucose deprivation (i.e. under hypoglycaemic conditions) can affect brain function, it has become apparent that low-level fluctuations in central availability can affect neural and consequently, cognitive performance. In the present paper the impact of diet-based glycaemic response and glucose regulation on cognitive processes across the lifespan will be reviewed. The data suggest that although an acute rise in blood glucose levels has some short-term improvements of cognitive function, a more stable blood glucose profile, which avoids greater peaks and troughs in circulating glucose is associated with better cognitive function and a lower risk of cognitive impairments in the longer term. Therefore, a habitual diet that secures optimal glucose delivery to the brain in the fed and fasting states should be most advantageous for the maintenance of cognitive function. Although the evidence to date is promising, it is insufficient to allow firm and evidence-based nutritional recommendations. The rise in obesity, diabetes and metabolic syndrome in recent years highlights the need for targeted dietary and lifestyle strategies to promote healthy lifestyle and brain function across the lifespan and for future generations. Consequently, there is an urgent need for hypothesis-driven, randomised controlled trials that evaluate the role of different glycaemic manipulations on cognition.

Item Type:
Journal Article
Journal or Publication Title:
Proceedings of the Nutrition Society
Additional Information:
https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/impact-of-dietbased-glycaemic-response-and-glucose-regulation-on-cognition-evidence-across-the-lifespan/76A622C316C2C1DC34D9D9FB0F6653B0 The final, definitive version of this article has been published in the Journal, Proceedings of the Nutrition Society, 76 (4), pp 466-477 2017, © 2017 Cambridge University Press.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2900/2916
Subjects:
ID Code:
87002
Deposited By:
Deposited On:
21 Jul 2017 15:38
Refereed?:
Yes
Published?:
Published
Last Modified:
27 Sep 2020 03:58