Electroactive polymeric scaffolds and method for delivering nerve growth factor to nerve tissue

Hardy , John George (2014) Electroactive polymeric scaffolds and method for delivering nerve growth factor to nerve tissue. WO2016044531A1.

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Abstract

A polymerizable unit that yields an electrochemically responsive polymer (advantageously pyrrole) is anchored by polymerization within a polycaprolactone matrix to form an electroactive scaffold upon which cells can be cultured and in which the micro- and nano-topological features of the polycaprolactone matrix are preserved. A scaffold manufactured in accordance with the preferred embodiment can support Schwann cells, which produce nerve growth factor when electrically stimulated. Nerve growth factor has been demonstrated to promote the regeneration of nerve tissue. By implanting the scaffold on which Schwann cells have been cultured into damaged nerve tissue and applying a voltage across the scaffold, nerve growth factor is produced, thereby promoting repair of the damaged nerve tissue.

Item Type:
Patent
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2200/2204
Subjects:

ID Code:
86371
Deposited By:
Deposited On:
22 May 2017 09:20
Refereed?:
No
Published?:
Published
Last Modified:
17 Aug 2020 09:50