Adverse drug events - analysis of a decade.:A Portuguese case-study, from 2004 to 2013 using hospital database

Scripcaru, Gianina and Caixeiro Mateus, Maria Do Ceu and Nunes, Carla (2017) Adverse drug events - analysis of a decade.:A Portuguese case-study, from 2004 to 2013 using hospital database. PLoS ONE, 12 (6). ISSN 1932-6203

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Abstract

Purpose. The goal of this study was to characterise adverse drug events (ADE), including both adverse drug reaction (ADR) and accidental poisoning by drugs (AP), considering age, gender, length of stay (LOS), number of deaths and year, during the period 2004-2013. Additionally distributions of the ten's most frequent ADR and AP were characterized, considering age-group and gender. Methods. A retrospective descriptive nationwide study was conducted, based on the hospital discharges database in Portugal from 2004 to 2013, using ICD-9. Events were identified based on the following codes: from E930 to E949.9 and from E850 to E858.9. Results. A total of 9 320 076 patients were discharged within this period, with 133 688 patients (1.46%) having at least one ADE, 4% of them related with AP. The mean age of these patients was 63.79 years (SD 21.31), 54.50 % were female and the mean LOS was 14.05 days (SD 22.19). Patient with AP had a mean age of 41.06 years (SD 34.05), 54.70 % were female and LOS was 7.15 days (SD 19.42). We have identified 10.691 deaths that represent 8.00 % from the total of patients with an ADE. The patients above 65 years were more affected by ADR and children below 18 were more affected by AP. Conclusion. In the last decade an increasing trend of ADR were observed and an AP pattern relatively stable. Elderly people and children were the age groups most affected. Antibiotics (in ADR) and benzodiazepine-based tranquilizers (in AP) were the major problems. This is a huge, increasing and challenging problem. Further research, using individual and contextual risk factors should be developed to understand spatiotemporal variability, promoting tailored interventions, within and across countries.

Item Type:
Journal Article
Journal or Publication Title:
PLoS ONE
Additional Information:
© 2017 Scripcaru et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700
Subjects:
ID Code:
86360
Deposited By:
Deposited On:
31 May 2017 14:24
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Sep 2020 03:46