Origins of DNA replication in the three domains of life

Robinson, Nicholas P. and Bell, Stephen D. (2005) Origins of DNA replication in the three domains of life. FEBS Journal, 272 (15). pp. 3757-3766. ISSN 1742-464X

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Abstract

Replication of DNA is essential for the propagation of life. It is somewhat surprising then that, despite the vital nature of this process, cellular organisms show a great deal of variety in the mechanisms that they employ to ensure appropriate genome duplication. This diversity is manifested along classical evolutionary lines, with distinct combinations of replicon architecture and replication proteins being found in the three domains of life: the Bacteria, the Eukarya and the Archaea. Furthermore, although there are mechanistic parallels, even within a given domain of life, the way origins of replication are defined shows remarkable variation.

Item Type: Journal Article
Journal or Publication Title: FEBS Journal
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1300/1312
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 86203
Deposited By: ep_importer_pure
Deposited On: 04 May 2017 13:14
Refereed?: Yes
Published?: Published
Last Modified: 26 Feb 2020 03:52
URI: https://eprints.lancs.ac.uk/id/eprint/86203

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