Origins of DNA replication in the three domains of life

Robinson, Nicholas P. and Bell, Stephen D. (2005) Origins of DNA replication in the three domains of life. FEBS Journal, 272 (15). pp. 3757-3766. ISSN 1742-464X

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Replication of DNA is essential for the propagation of life. It is somewhat surprising then that, despite the vital nature of this process, cellular organisms show a great deal of variety in the mechanisms that they employ to ensure appropriate genome duplication. This diversity is manifested along classical evolutionary lines, with distinct combinations of replicon architecture and replication proteins being found in the three domains of life: the Bacteria, the Eukarya and the Archaea. Furthermore, although there are mechanistic parallels, even within a given domain of life, the way origins of replication are defined shows remarkable variation.

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Journal Article
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FEBS Journal
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04 May 2017 13:14
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18 Sep 2023 01:11