End-resection at DNA double-strand breaks in the three domains of life

Blackwood, John K. and Rzechorzek, Neil J. and Bray, Sian M. and Maman, Joseph D. and Pellegrini, Luca and Robinson, Nicholas P. (2013) End-resection at DNA double-strand breaks in the three domains of life. Biochemical Society Transactions, 41 (1). pp. 314-320. ISSN 0300-5127

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Abstract

During DNA repair by HR (homologous recombination), the ends of a DNA DSB (double-strand break) must be resected to generate single-stranded tails, which are required for strand invasion and exchange with homologous chromosomes. This 5'-3' end-resection of the DNA duplex is an essential process, conserved across all three domains of life: the bacteria, eukaryota and archaea. In the present review, we examine the numerous and redundant helicase and nuclease systems that function as the enzymatic analogues for this crucial process in the three major phylogenetic divisions.

Item Type:
Journal Article
Journal or Publication Title:
Biochemical Society Transactions
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1303
Subjects:
ID Code:
86191
Deposited By:
Deposited On:
04 May 2017 09:12
Refereed?:
Yes
Published?:
Published
Last Modified:
07 Jan 2020 05:23