Caenorhabditis elegans:an emerging model in biomedical and environmental toxicology

Leung, Maxwell C. K. and Williams, Phillip L. and Benedetto, Alexandre and Au, Catherine and Helmcke, Kirsten J. and Aschner, Michael and Meyer, Joel N. (2008) Caenorhabditis elegans:an emerging model in biomedical and environmental toxicology. Toxicological sciences : an official journal of the Society of Toxicology, 106 (1). pp. 5-28. ISSN 1096-0929

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Abstract

The nematode Caenorhabditis elegans has emerged as an important animal model in various fields including neurobiology, developmental biology, and genetics. Characteristics of this animal model that have contributed to its success include its genetic manipulability, invariant and fully described developmental program, well-characterized genome, ease of maintenance, short and prolific life cycle, and small body size. These same features have led to an increasing use of C. elegans in toxicology, both for mechanistic studies and high-throughput screening approaches. We describe some of the research that has been carried out in the areas of neurotoxicology, genetic toxicology, and environmental toxicology, as well as high-throughput experiments with C. elegans including genome-wide screening for molecular targets of toxicity and rapid toxicity assessment for new chemicals. We argue for an increased role for C. elegans in complementing other model systems in toxicological research.

Item Type:
Journal Article
Journal or Publication Title:
Toxicological sciences : an official journal of the Society of Toxicology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000/3005
Subjects:
ID Code:
86168
Deposited By:
Deposited On:
03 May 2017 10:12
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Sep 2020 03:45