Manganese transport in eukaryotes:the role of DMT1

Au, Catherine and Benedetto, Alexandre and Aschner, Michael (2008) Manganese transport in eukaryotes:the role of DMT1. NeuroToxicology, 29 (4). pp. 569-576. ISSN 0161-813X

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Manganese (Mn) is a transition metal that is essential for normal cell growth and development, but is toxic at high concentrations. While Mn deficiency is uncommon in humans, Mn toxicity is known to be readily prevalent due to occupational overexposure in miners, smelters and possibly welders. Excessive exposure to Mn can cause Parkinson's disease-like syndrome; patients typically exhibit extrapyramidal symptoms that include tremor, rigidity and hypokinesia [Calne DB, Chu NS, Huang CC, Lu CS, Olanow W. Manganism and idiopathic parkinsonism: similarities and differences. Neurology 1994;44(9):1583-6; Dobson AW, Erikson KM, Aschner M. Manganese neurotoxicity. Ann NY Acad Sci 2004;1012:115-28]. Mn-induced motor neuron diseases have been the subjects of numerous studies; however, this review is not intended to discuss its neurotoxic potential or its role in the etiology of motor neuron disorders. Rather, it will focus on Mn uptake and transport via the orthologues of the divalent metal transporter (DMT1) and its possible implications to Mn toxicity in various categories of eukaryotic systems, such as in vitro cell lines, in vivo rodents, the fruitfly, Drosophila melanogaster, the honeybee, Apis mellifera L., the nematode, Caenorhabditis elegans and the baker's yeast, Saccharomyces cerevisiae.

Item Type: Journal Article
Journal or Publication Title: NeuroToxicology
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/3000/3005
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 86167
Deposited By: ep_importer_pure
Deposited On: 03 May 2017 10:10
Refereed?: Yes
Published?: Published
Last Modified: 29 Jan 2020 03:54

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