Sensing platform based on laser-engineered nanocomposite glass

Zolotovskaya, Svetlana and Abdolvand, Amin (2016) Sensing platform based on laser-engineered nanocomposite glass. In: Photon16. IOP Publishing Ltd, p. 79.

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Surface-Enhanced Raman Scattering (SERS) is an extremely powerful optical detection platform for the development of sensitive and quantitative analytical methods suitable for real-time monitoring. This technique provides information about the vibronic ‘fingerprint’ of a molecule located close to plasmonic nanostructures and therefore allows for a unique classification of the sort of analyte detected. This method has also been proven to have a single-molecule detection capability. SERS-based approaches have enabled a number of important applications in bioanalytical sensing, such as in-vivo tumour targeting, glucose sensing at clinically relevant concentrations and microbial system analysis, and are considered a major prerequisite for progress in areas such as nanobiotechnology and personalised medicine. In this work the focus is on the development of novel SERS substrates based on laser-engineered nanocomposite glasses. The controllable laser-assisted fabrication of regular monolayers of silver nanoparticles with high density and narrow size distribution is reported. The effect of size and nanoparticle density on SERS signal is examined using Rhodamine 6G (R6G), pyridine and benzenethiol at different concentrations and excitation wavelengths. These sensing platforms benefit from inexpensive and large-scale controllable fabrication, robustness and ease of integration into microfluidic devices for rapid multiplexed SERS assays.

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30 Mar 2017 12:58
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12 Sep 2023 02:13