An early and sustained peripheral inflammatory response in acute ischaemic stroke:relationships with infection and atherosclerosis

Emsley, Hedley C. A. and Smith, Craig J. and Gavin, Carole M. and Georgiou, Rachel F. and Vail, Andy and Barberan, Elisa M. and Hallenbeck, John M. and Del Zoppo, Gregory J. and Rothwell, Nancy J. and Tyrrell, Pippa J. and Hopkins, Stephen J. (2003) An early and sustained peripheral inflammatory response in acute ischaemic stroke:relationships with infection and atherosclerosis. Journal of Neuroimmunology, 139 (1-2). pp. 93-101. ISSN 0165-5728

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Abstract

Central nervous system and peripheral inflammation is important in the responses to ischaemic stroke, and may also predispose to its development. We aimed to identify (1) the extent to which a peripheral inflammatory response is activated in patients following acute stroke, and (2) whether there was evidence for preexisting peripheral inflammation. Thirty-six patients with ischaemic stroke within 12 h of onset of symptoms had serial blood samples taken up to 12 months for analysis of markers of inflammation. Thirty-six control subjects, individually matched for age, sex and degree of atherosclerosis, were also studied. Median C-reactive protein (CRP) was elevated, relative to controls (2.08 mg/l), from admission (4.31 mg/l) (p≤0.001) until 3 months (2.90 mg/l) (p≤0.01), the greatest elevation occurring at 5-7 days (17.67 mg/l) (p≤0.001). Elevations were also seen in erythrocyte sedimentation rate (ESR) and white blood cell (WBC) count until 3 months. Median plasma IL-6 was also elevated, relative to controls (9 pg/ml), by 24 h after onset of symptoms (22 pg/ml) (p≤0.01), and remained elevated at 5-7 days (23 pg/ml) (p≤0.01), but not at 3 months. Less marked elevations in these markers were seen in patients without evidence of infection except for IL-6, which was not increased in the absence of infection. These data provide evidence of an early and sustained peripheral inflammatory response to acute ischaemic stroke in patients with or without evidence of infection. The very early increase in concentrations of inflammatory markers after stroke may either be induced by stroke itself, or may indicate a preexisting inflammatory condition in stroke patients which may contribute to the development of stroke.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Neuroimmunology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2808
Subjects:
ID Code:
84795
Deposited By:
Deposited On:
21 Feb 2017 09:52
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Oct 2020 04:11