Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

Smith, Craig J. and Emsley, Hedley C. A. and Gavin, Carole M. and Georgiou, Rachel F. and Vail, Andy and Barberan, Elisa M. and del Zoppo, Gregory J. and Hallenbeck, John M. and Rothwell, Nancy J. and Hopkins, Stephen J. and Tyrrell, Pippa J. (2004) Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurology, 4. ISSN 1471-2377

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Abstract

Background: Cerebral ischaemia initiates an inflammatory response in the brain and periphery. We assessed the relationship between peak values of plasma interleukin-6 (IL-6) in the first week after ischaemic stroke, with measures of stroke severity and outcome. Methods: Thirty-seven patients with ischaemic stroke were prospectively recruited. Plasma IL-6, and other markers of peripheral inflammation, were measured at pre-determined timepoints in the first week after stroke onset. Primary analyses were the association between peak plasma IL-6 concentration with both modified Rankin score (mRS) at 3 months and computed tomography (CT) brain infarct volume. Results: Peak plasma IL-6 concentration correlated significantly (p <0.001) with CT brain infarct volume (r = 0.75) and mRS at 3 months (r = 0.72). It correlated similarly with clinical outcome at 12 months or stroke severity. Strong associations were also noted between either peak plasma Creactive protein (CRP) concentration or white blood cell (WBC) count, and all outcome measures. Conclusions: These data provide evidence that the magnitude of the peripheral inflammatory response is related to the severity of acute ischaemic stroke, and clinical outcome.

Item Type: Journal Article
Journal or Publication Title: BMC Neurology
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2700/2728
Subjects:
Departments: Faculty of Health and Medicine > Medicine
ID Code: 84792
Deposited By: ep_importer_pure
Deposited On: 21 Feb 2017 09:58
Refereed?: Yes
Published?: Published
Last Modified: 23 Jan 2020 03:48
URI: https://eprints.lancs.ac.uk/id/eprint/84792

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