Counteracting bone fragility with amniotic fluid-derived fetal stem cells

Ranzoni, Anna and Corcelli, Michelangelo and Hau, Kwan-Leong and Kerns, Jemma Gillian and Vanleene, Maximillien and Shefelbine, Sandra and Jones, Gemma and Moschidou, Dafni and Dala-Ali, Benan and Goodship, Allen and Arnett, Timothy and Guillot, Pascale (2016) Counteracting bone fragility with amniotic fluid-derived fetal stem cells. Scientific Reports, 6. ISSN 2045-2322

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Abstract

The impaired maturation of bone-forming osteoblasts results in reduced bone formation and subsequent bone weakening, which leads to a number of conditions such as osteogenesis imperfecta (OI). Transplantation of human fetal mesenchymal stem cells has been proposed as skeletal anabolic therapy to enhance bone formation, but the mechanisms underlying the contribution of the donor cells to bone health are poorly understood and require further elucidation. Here, we show that intraperitoneal injection of human amniotic mesenchymal stem cells (AFSCs) into a mouse model of OI (oim mice) reduced fracture susceptibility, increased bone strength, improved bone quality and micro-architecture, normalised bone remodelling and reduced TNFα and TGFβ sigalling. Donor cells engrafted into bones and differentiated into osteoblasts but importantly, also promoted endogenous osteogenesis and the maturation of resident osteoblasts. Together, these findings identify AFSC transplantation as a countermeasure to bone fragility. These data have wider implications in for bone health and fracture reduction.

Item Type:
Journal Article
Journal or Publication Title:
Scientific Reports
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1000
Subjects:
ID Code:
83352
Deposited By:
Deposited On:
20 Dec 2016 08:52
Refereed?:
Yes
Published?:
Published
Last Modified:
28 Apr 2020 04:19