Preparation, characterization and in vitro antioxidant and cytotoxicity studies of some 2,4-dichloro-N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives

Gunasekaran, Nanjappan and Vadivel, Vellingiri and Halcovitch, Nathan R. and Tiekink, Edward R.T. (2017) Preparation, characterization and in vitro antioxidant and cytotoxicity studies of some 2,4-dichloro-N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives. Chemical Data Collections, 9-10. pp. 263-276. ISSN 2405-8300

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Abstract

Abstract In the present study, three biologically active, substituted acyl thiourea compounds (1–3) have been synthesized from 2,4-dichlorobenzoyl chloride, potassium thiocyanate and the corresponding secondary amine in dry acetone. As analytical and spectral data of 1 and 3 have already been discussed in the literature, only the compound 2 was characterized by elemental analyses, UV–Visible, FT–IR, 1H & 13C NMR spectroscopic techniques. The molecular structures of 1–3 were determined by single crystal X-ray crystallography which shows twists of up to 70° about the (S=)C–NC(=O) bonds. All the synthesized compounds show good antioxidant property and cytotoxic potential against Ehrlich Ascites Carcinoma (EAC) cancer cell line.

Item Type:

Journal Article

Journal or Publication Title:

Chemical Data Collections

Additional Information:

This is the author’s version of a work that was accepted for publication in Chemical Data Collections. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Data Collections, 9-10, 2017 DOI: 10.1016/j.cdc.2016.11.007

Subjects:

?? thiourea derivativesx-ray crystallographyantioxidant activitycytotoxicityeac cell line ??

ID Code:

83281

Deposited By:

ep_importer_pure

Deposited On:

30 Nov 2016 13:38

Refereed?:

Yes

Published?:

Published

Last Modified:

31 Dec 2023 00:46

URI:

https://eprints.lancs.ac.uk/id/eprint/83281