A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease

Salles, Geisa Nogueira and Pereira, Fernanda Aparecida dos Santos and Pacheco-Soares, Cristina and Marciano, Fernanda Roberta and Holscher, Christian and Webster, Thomas J. and Lobo, Anderson Oliveira (2017) A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease. Molecular Neurobiology, 54 (9). pp. 6827-6838. ISSN 0893-7648

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Abstract

Bioresorbable electrospun fibres have highly functional features that can preserve drug efficacy, avoiding premature degradation, and control drug release rates over long periods. In parallel, it is known that Alzheimer’s disease (AD) has been linked to impaired insulin signalling in the brain. Glucagon-like peptide 1 (GLP-1) analogues have beneficial effects on insulin release and possess exceptional neuroprotective properties. Herein, we describe for the first time the incorporation of a GLP-1 analogue, liraglutide, into electrospun poly (lactic acid) (PLA) fibres with in situ gelatin capsules, in order to provide the controlled release of liraglutide, improving neuroprotective properties. In this study, PLA, a bioresorbable polymer in which degradation products have neurogenesis characteristics, was electrospun and loaded with liraglutide. Moreover, PLA/liraglutide fibres were encapsulated with gelatin and were shown to have better properties than the non-encapsulated fibres in terms of the controlled release of liraglutide, which was accomplished in the present study for up to 60 days. We observed that this biodevice was completely encapsulated with gelatin, which made the material more hydrophilic than PLA fibres alone and the biodevice was able to enhance fibroblast interaction and reduce mitochondrial stress in a neuroblastoma cell line. In this manner, this study introduces a new material which can improve neuroprotective properties from AD oxidative stress via the sustained long-lasting release of liraglutide.

Item Type:
Journal Article
Journal or Publication Title:
Molecular Neurobiology
Additional Information:
The final publication is available at Springer via http://dx.doi.org/10.1007/s12035-016-0200-0
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2804
Subjects:
ID Code:
82954
Deposited By:
Deposited On:
02 Dec 2016 15:18
Refereed?:
Yes
Published?:
Published
Last Modified:
05 Jul 2020 05:26