Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia.

Ettinger, Ulrich and Kumari, Veena and Crawford, Trevor J. and Corr, Philip J. and Das, Mrigendra and Zachariah, Elizabeth and Hughes, Catherine and Sumich, Alex L. and Rabe-Hesketh, Sophia and Sharma, Tonmoy (2004) Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia. Journal of Psychiatric Research, 38 (2). pp. 177-184.

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Smooth pursuit eye movement (SPEM) and antisaccade deficits have been proposed as endophenotypes in the search for schizophrenia genes. We assessed these measures in 24 schizophrenia patients, 24 of their healthy siblings, and 24 healthy controls closely matched to the siblings. Between-group differences were assessed using a random effects regression model taking into account the relatedness between patients and siblings. Patients showed reduced SPEM gain, increased frequency of saccades during pursuit, increased antisaccade error rate, and reduced antisaccade gain compared to controls. Siblings performed intermediate, i.e. between patients and controls, on most measures, but were particularly characterised by reduced antisaccade gain. SPEM gain at one target velocity was significantly correlated between patients and siblings, highlighting the necessity of taking into account within-family correlations in the statistical analysis of between-group differences. It is concluded that subtle SPEM and antisaccade deficits are observed in clinically unaffected siblings of schizophrenia patients; these deficits may be useful markers of genetic liability to schizophrenia.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Psychiatric Research
Uncontrolled Keywords:
?? schizophreniaendophenotypegeneticssmooth pursuit eye movementsantisaccadefirst-degree relativespsychiatry and mental healthbiological psychiatrybf psychology ??
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Deposited On:
08 Oct 2016 00:06
Last Modified:
15 Jul 2024 09:11